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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
16.97
Human Site:
T506
Identified Species:
26.67
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
T506
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
T506
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
T506
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Dog
Lupus familis
XP_543464
544
61233
T507
L
S
E
E
K
K
S
T
A
L
L
Q
V
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
S509
L
L
V
Q
E
K
N
S
V
T
L
P
V
A
P
Rat
Rattus norvegicus
NP_446129
545
60912
L508
L
L
V
Q
E
K
N
L
V
P
L
P
L
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
I489
L
M
Q
Q
K
E
S
I
A
L
P
Q
H
P
I
Chicken
Gallus gallus
NP_001073576
522
58779
M483
L
A
Q
T
S
A
T
M
N
P
P
Q
T
S
K
Frog
Xenopus laevis
NP_001082016
517
58243
T477
L
M
Y
G
V
D
H
T
M
P
P
P
I
K
K
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
Q388
C
H
S
T
K
S
S
Q
S
T
R
S
S
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
R442
V
L
Q
S
S
W
L
R
D
A
P
M
L
Q
K
Honey Bee
Apis mellifera
XP_624334
480
54300
S446
E
S
I
D
M
I
L
S
K
E
N
D
E
N
I
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
R442
W
M
K
C
A
D
C
R
T
A
K
Q
D
I
L
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
K445
I
G
C
M
S
S
R
K
M
S
R
S
D
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
H477
N
I
D
E
A
L
N
H
P
W
F
N
D
I
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
100
73.3
N.A.
13.3
6.6
N.A.
46.6
20
20
6.6
N.A.
6.6
6.6
6.6
0
P-Site Similarity:
100
100
100
80
N.A.
40
33.3
N.A.
60
46.6
33.3
20
N.A.
33.3
20
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
14
7
0
0
34
14
0
0
0
14
27
% A
% Cys:
7
0
7
7
0
0
7
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
7
0
14
0
0
7
0
0
7
20
7
0
% D
% Glu:
7
0
27
34
14
27
0
0
0
7
0
0
7
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% F
% Gly:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
7
0
0
0
0
7
7
0
0
0
0
7
0
0
% H
% Ile:
7
7
7
0
0
7
0
7
0
0
0
0
7
14
14
% I
% Lys:
0
0
7
0
20
20
0
7
7
0
7
0
0
7
20
% K
% Leu:
60
20
0
0
0
7
14
7
0
34
20
0
14
20
7
% L
% Met:
0
20
0
7
7
0
0
7
14
0
0
7
0
0
0
% M
% Asn:
7
0
0
0
20
0
20
0
7
0
7
7
0
7
0
% N
% Pro:
0
0
0
0
0
0
0
0
7
20
47
20
0
14
14
% P
% Gln:
0
0
20
20
0
0
0
7
0
0
0
47
0
7
7
% Q
% Arg:
0
0
0
0
0
0
7
14
0
0
14
0
0
7
0
% R
% Ser:
0
34
7
7
20
14
40
14
7
7
0
14
7
7
14
% S
% Thr:
0
0
0
14
0
0
7
34
7
14
0
0
7
0
0
% T
% Val:
7
0
14
0
7
0
0
0
14
0
0
0
34
0
0
% V
% Trp:
7
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _